Radiochemistry Services
Our radiochemistry team has radiolabeled hundreds of biological agents and small molecules for preclinical and clinical trial imaging. From targeted small molecules to monoclonal antibodies, peptides, and live cell labeling, we provide expertise across a diverse range of chemical entities.
Additionally, we offer ligand discovery support, leveraging our in-house expertise to optimize candidate selection.
- 900+ agents radiolabeled
- Extensive experience with US and UK/EU GMP regulatory requirements
- 80+ IND submissions supported for novel radiotracers
- Significant supply chain capabilities, supporting 300 global production centers
- External manufacturing offering covering US, EU, APAC, and Oceania, including site identification, qualification, set up, validation, and oversight
Capabilities
Our radiochemistry services are designed to reliably deliver high-quality radiotracers tailored precisely to meet your project needs.
Radiotracer Support
- Radiohalogenations and radiometal chelations according to GMP manufacturing in accordance with FDA, MHRA, and EMA requirements
- Expertise in automated synthesis modules
- Ligands: low molecular weight, proteins, biologics
- Cu-64, In-111, Zr-89, Ga-68, in-house cyclotrons for C-11/F-18 production
- Rapid site-to-site method transfer, tracer manufacturing and shipping, and outsourcing of carbon-14 and tritium labeling
Quality Control
- HPLC/UPLC, UV-Vis spectrophotometry, GC for residual solvent analysis
- Bioactivity, immunoreactivity, and metabolite analysis (blood, urine, brain)
- Cell/tissue binding and internalization assay development
- CMP/urine metabolic health analysis, SDS-PAGE
- Gamma counters, dose calibrators, radio-TLC scanners, and autoradiography
Isotopes/Modalities
Perceptive has extensive experience working with widely used SPECT/PET and therapeutic isotopes.
We also support conjugation with fluorophores as well as ‘cold’ radiolabeling with non-radioactive elements.
PET Isotopes
- Commonly used:
• ¹¹C, ¹³N, ¹⁵O, ¹⁸F, ⁶⁴Cu, ⁶⁸Ga, ⁸⁹Zr, ¹²⁴I - Emerging & specialized:
• ⁸⁶Y, ⁵²Mn
SPECT Isotopes
- Short-lived:
• ⁹⁹ᵐTc, ¹²³I - Long-lived:
• ¹¹¹In, ¹²⁵I, ²⁰³Pb, ²⁰¹Tl, ⁶⁷Ga, ⁷⁵Se
Therapeutic Isotopes
- Beta emitters:
• ¹³¹I, ¹⁷⁷Lu, ⁹⁰Y, ¹⁸⁶Re, ¹⁸⁸Re - Alpha emitters:
• ²²⁵Ac, ²²⁷Ac, ²¹²Pb, ²¹¹At (notably emerging in alpha therapy)
Others:
• ¹⁶¹Tb, ⁶⁷Cu
Specialized Experience in Astatine-211 (²¹¹At)
Perceptive is one of the few imaging and radiochemistry providers with proven radiolabeling capabilities using ²¹¹At, a highly promising alpha emitter in next-generation radiopharmaceutical therapies. Our team brings deep knowledge of its chelation chemistry, stability challenges, and safety protocols—enabling accelerated early-phase research in this emerging class of therapeutics.
Medicinal Chemistry
Perceptive provides extensive support for small molecule ligand development, offering guidance on candidate selection from sponsor compound libraries or the production of custom precursors and standards for preclinical studies to maximize your chances of success. We also facilitate custom GMP precursor manufacturing through our trusted partners.
Your Work is Global and So Are We
Perceptive offers in-house radiochemistry and clinical services, oversees clinical manufacturing at external sites, and produces and supplies radiotracers to imaging sites across the US and UK. We also facilitate access to a global network of radiotracer manufacturers, enabling GMP manufacturing at one of our sites with subsequent technology transfer to one of many perceptive-qualified sites based on geographical needs.
Our team also has extensive experience collaborating with external manufacturers to optimize and advance new tracers for IND applications and support NDA submissions for commercial use.
Frequently Asked Questions
1. What types of molecules can Perceptive radiolabel?
Our radiochemistry team has extensive experience radiolabeling a wide variety of molecules, including small molecules, monoclonal antibodies, peptides, proteins, and live cell labels. This versatility enables us to support programs across oncology, neuroscience, and radiopharmaceutical therapy.
2. How does Perceptive ensure radiolabeling quality and reproducibility?
We apply rigorous analytical and quality control methods, including HPLC/UPLC, GC, immunoreactivity testing, and metabolite analysis, to confirm purity, stability, and biological activity. These processes ensure radiolabeled compounds are suitable for preclinical evaluation and translational research.
3. What support does Perceptive provide for regulatory submissions?
Our team has contributed to more than 80 IND submissions for novel radiotracers. We provide the documentation, method validation, and regulatory-ready data needed to advance radiopharmaceutical programs confidently into clinical development.
4. How does Perceptive manage global radiochemistry manufacturing?
Through an established network of over 300 global manufacturing sites, we support clients with site identification, qualification, setup, validation, and oversight. This ensures reliable, compliant production across the US, EU, APAC, and Oceania.
5. Does Perceptive offer specialized radiochemistry expertise?
Beyond routine radiolabeling, we provide ligand discovery support and medicinal chemistry guidance, including work with challenging isotopes such as Astatine-211 (²¹¹At). Our team develops custom precursors, standards, and radiolabeling strategies to accelerate radiopharmaceutical discovery.
How Can We Help?
Reach out today, and one of our solution experts will be in touch to learn about your specific needs.
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